A targeted sleep-support formulation designed to assist circadian rhythm regulation and sleep continuity during menopause and perimenopause. This formulation combines melatonin with calming botanicals and neuromodulatory compounds to support sleep onset, duration, and overall sleep quality during hormonally mediated sleep disruption.

All batch testing and Certificates of Analysis are available in the Menopause Science Trust Center.

Clinical Profile

Targets

• Sleep onset latency

• Nighttime awakenings

• Sleep fragmentation

• Circadian rhythm disruption

• Sleep quality during hormonal transition

Primary Active

Melatonin
A naturally occurring hormone involved in circadian rhythm regulation and sleep–wake signaling.

Formulation Rationale

Sleep disruption during menopause is associated with changes in circadian signaling, neurochemical balance, and stress response.

This formulation combines melatonin with a complementary calming matrix to address both circadian regulation and nervous system relaxation:

GABA
A primary inhibitory neurotransmitter involved in promoting relaxation and reducing neural excitability.

Passionflower
Traditionally used to support relaxation and reduce sleep latency.

Valerian Root
Studied for its role in supporting sleep continuity and reducing nighttime awakenings.

The formulation is designed to support multiple physiological pathways involved in sleep initiation and maintenance without next-day sedation.

Key Characteristics

• Melatonin-based circadian support

• Multi-pathway sleep formulation

• Non-habit forming

• Designed for nightly use

• Vegan

• Non-GMO

• Gluten-free

• Free from artificial colors and preservatives

• Third-party tested

• Manufactured in an FDA-registered, GMP-certified facility

Full Ingredient List

Melatonin
GABA
Passionflower Extract
Valerian Root Extract
Vegetable Capsule
Inactive excipients

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Trust Center Verified

Comprehensive analysis of clinical research and evidence*

Sleep Science By Menopause Science

Declining estrogen disrupts your natural sleep-wake cycle, while anxiety about life changes and physical discomfort create a perfect storm of sleeplessness.*

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Research Summary

Research demonstrates that sleep disruption affects approximately 61% of women during the menopausal transition, often beginning during perimenopause and persisting beyond the final menstrual period. Clinical studies specifically in menopausal and postmenopausal women have shown that targeted natural sleep support can significantly improve sleep quality, reduce anxiety, and support healthy circadian rhythms during hormonal transitions.*

Research at a Glance

Plain Language Summary

Melatonin is well-tolerated in menopausal women with no reports of serious adverse effects in clinical trials. Valerian has a centuries-long history of traditional use, and recent clinical studies have confirmed its safety in postmenopausal women. Chamomile and lavender are generally recognized as safe with minimal side effects. Some women may experience mild drowsiness the next morning when first starting. If this occurs, consider taking it earlier in the evening. Not recommended during pregnancy or breastfeeding. Always consult your healthcare provider before starting any new supplement regimen.*

Key Citations

Primary Research in Women In Phases of Menopause:

1. Sleep, melatonin, and the menopausal transition: what are the links? Sleep Sci. 2017;10(1):11-18. PMC: 5611767

2. Effect of valerian on sleep quality in postmenopausal women: a randomized placebo-controlled clinical trial. Menopause. 2011;18(9):951-5. PubMed: 21775910

Supporting Anxiety & Sleep Research:

1. Comparison of the effectiveness of lavender and chamomile herbal tea on anxiety and depression in postmenopausal women. Women's Health Bull. 2022;9(3):172-180. Clinical Trial

2. The effect of oral chamomile on anxiety: a systematic review of clinical trials. Clin Nutr Res. 2024;13(2):139-147. PMC: 11109927

3. Lavender and the nervous system. Evid Based Complement Alternat Med. 2013;2013:681304. PMC: 3612440

Bedtime Bliss in One Little Strip

A science-guided formula designed with your rest in mind. Try it today.

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Important Disclaimer

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Always consult with your healthcare provider before starting any new supplement regimen, especially if you have pre-existing health conditions or are taking medications.

The research cited represents studies conducted on individual ingredients and may not reflect the specific formulation of this product. Individual results may vary based on sleep hygiene, stress levels, health status, and other factors. The research cited represents potential benefits and does not guarantee specific outcomes for all users.